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Testosterone Replacement Therapy

Understanding Testosterone Replacement Therapy (TRT) for Men

What is Testosterone?

Testosterone is the primary male sex hormone, crucial for developing male reproductive tissues, maintaining muscle mass, bone density, and regulating libido. Beyond these functions, testosterone also plays a significant role in mood, energy levels, and overall well-being.

How Does Testosterone Change with Age?

As men age, testosterone levels naturally decline. This process typically begins around age 30 and continues gradually over the years. After the age of 40, testosterone levels decrease by 1-2% per year. By the time men reach their 40s and 50s, this decline may become more noticeable, often resulting in symptoms that can affect their quality of life. This state of low testosterone is called hypogonadism.

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Risks and Symptoms

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Fatigue and Energy Levels

Many men with low testosterone feel persistently tired, even after adequate rest.
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Mood Changes

Low testosterone can contribute to feelings of depression, irritability, or a lack of motivation.
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Heart Health

Research studies have shown that low testosterone levels in aging men leads to in increased risk of heart disease and death from cardiovascular disease.
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Decreased Muscle Mass and Increased Fat

Testosterone is essential for maintaining muscle mass. Low levels can lead to muscle loss and an increase in body fat, particularly around the abdomen. Visceral fat (belly fat) is very unhealthy and also increases with declining testosterone levels, and can in turn reduce testosterone levels even further.
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Bone Density

Testosterone plays a role in bone health, and low levels can increase the risk of osteoporosis and fractures.
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Reduced Libido

One of the most noticeable effects is a decrease in sexual desire and can also lead to erectile dysfunction.

What to Expect and When

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2-4 Weeks

Improved energy, mood, and mental clarity; enhanced libido and sense of well-being.
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4-8 Weeks

Increased muscle mass, reduced body fat, improved sleep quality, and better endurance.
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3-6 Months

Further improvements in strength, bone density, fat loss, muscular definition; well-being.
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6+ Months

Sustained improvements in muscle mass, body composition, sexual function, and overall vitality.

Testosterone Therapy Treatment Methods

Testosterone Replacement Therapy (TRT) is a common treatment for men with low testosterone levels. The goal of TRT is to restore testosterone levels to a normal range, helping alleviate the symptoms of low testosterone. There are several methods available for testosterone therapy:

Testosterone Injections

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How It Works

Testosterone injections are administered directly into the muscle, typically every 1-2 weeks. This method delivers a specific dose of testosterone that is gradually absorbed into the bloodstream.
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Pros

Injections provide a consistent and controlled method of delivering testosterone, often resulting in noticeable and rapid improvements in symptoms.
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Cons

Some men may find injections inconvenient or uncomfortable. There may be some fluctuations in testosterone levels between doses.

Topical Creams and Gels

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How It Works

Testosterone injections are administered either directly into the muscle or subcutaneously, typically every 1-2 weeks. These methods deliver a specific dose of testosterone that is gradually absorbed into the bloodstream.
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Pros

This method is non-invasive and easy to use, with a steady release of testosterone throughout the day.
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Cons

There is a risk of transferring the testosterone to others through skin contact, and it may cause skin irritation. Additionally, absorption can be erratic and may not achieve the levels needed.

Considerations and Risks of Testosterone Therapy

While testosterone therapy can be beneficial for men with low testosterone, it is not without risks. Potential side effects include:

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Prostate Health

Testosterone therapy should not be used in men with a diagnosis of prostate cancer. A study published online Dec. 27, 2023, by JAMA Network Open confirms prior research showing that testosterone replacement therapy (TRT) in men with documented low testosterone levels does not increase their risk of prostate cancer compared to men not using TRT.
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Heart Conditions

TRT should be avoided in those with poorly controlled heart failure, recent myocardial infarction (MI), revascularization, or stroke.
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Sleep Apnea

Testosterone therapy can worsen sleep apnea in some men.

Is Testosterone Therapy Right for You?

If you suspect you have low testosterone, contact TransformRx. We will perform a testosterone panel blood test to measure your testosterone levels and discuss your symptoms and treatment. Testosterone therapy may be a suitable option if you have significantly low levels and are experiencing related symptoms.

However, testosterone therapy is not recommended for everyone. Men with certain conditions, such as prostate or breast cancer, should avoid TRT. Your healthcare provider will consider your overall health, risks, and benefits before recommending treatment. Additionally, after your therapy begins, we will monitor your levels of testosterone and other indicators to assure that you are taking adequate amounts while not causing other hormonal imbalances and side effects.